The E-Cadherin protein consists of an extracellular domain, a single transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for homophilic binding, meaning it binds to E-Cadherin molecules on adjacent cells. The cytoplasmic tail interacts with the cytoskeleton through catenins, specifically beta-catenin and alpha-catenin, facilitating strong cell-cell adhesion.
