In histology, E-Cadherin is commonly studied using immunohistochemistry (IHC) and immunofluorescence (IF) techniques. These methods allow for the visualization of E-Cadherin localization and expression levels in tissue sections. Antibodies specific to E-Cadherin are used to detect the protein, and the staining patterns can provide insights into tissue organization and integrity. Loss of E-Cadherin staining in tumor samples, for instance, can be indicative of tumor progression and poor prognosis.