The loss or dysfunction of E-Cadherin is strongly associated with cancer progression and metastasis. In many types of epithelial cancers, E-Cadherin expression is reduced or lost, leading to decreased cell-cell adhesion and increased cell mobility. This process facilitates the dissociation of cancer cells from the primary tumor, allowing them to invade surrounding tissues and spread to distant sites, a process known as the epithelial-mesenchymal transition (EMT).
