Dysregulation of PI3K signaling is implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. In cancer, mutations in the PI3K gene or loss of PTEN function can lead to uncontrolled cell proliferation and survival. In the context of diabetes, PI3K signaling is essential for insulin-mediated glucose uptake. Alterations in this pathway can result in insulin resistance. Additionally, recent studies have linked PI3K to cognitive functions and its potential role in Alzheimer's disease.
