What Is the Significance of Mitochondrial Membrane Potential?
The mitochondrial membrane potential (ΔΨm) is critical for mitochondrial function and cellular viability. During mitochondrial apoptosis, the ΔΨm is disrupted, leading to the release of apoptogenic factors such as cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor). The loss of ΔΨm is often considered an early and irreversible step in the apoptotic process.
