The process of labeling antigens with radioactive isotopes involves several steps: 1. Selection of Isotope: Commonly used isotopes include Iodine-125, Tritium, and Carbon-14. 2. Conjugation: The isotope is chemically linked to the antigen, often through a reactive group that forms a stable bond. 3. Verification: The labeled antigen is tested to ensure that the radioactive tag does not interfere with its biological activity.