cytochrome p450 enzymes

What is the Significance of Cytochrome P450 Enzymes in Toxicology?

The role of Cytochrome P450 enzymes in toxicology is profound. They are involved in the bioactivation of procarcinogens to carcinogens, contributing to the initiation of cancer. Additionally, these enzymes are implicated in the formation of reactive oxygen species (ROS), which can cause cellular damage. Understanding the distribution and activity of these enzymes in tissues is essential for assessing the toxicological impact of various substances.

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