What is the Role of Cytochrome P450 Enzymes in Drug Metabolism?
Cytochrome P450 enzymes are crucial in the metabolism of many drugs. They facilitate the oxidation of drugs, making them more soluble and easier to excrete. This process involves various phases of metabolism, including Phase I (functionalization reactions) and Phase II (conjugation reactions). Enzymes like CYP3A4, CYP2D6, and CYP2C9 are particularly important in the metabolism of pharmaceuticals.
