In the context of aging, SAHF formation in senescent cells contributes to the decline in tissue function. As more cells enter senescence and form SAHF, the regenerative capacity of tissues diminishes. This is particularly evident in tissues with high turnover rates, such as the skin and hematopoietic systems. However, the presence of SAHF also serves as a protective mechanism against the development of age-related diseases like cancer, by ensuring that damaged cells do not proliferate.
