Dysregulation of polyadenylation can be implicated in various diseases, including cancer and neurological disorders. Abnormalities in the polyadenylation process can lead to the production of unstable or improperly localized mRNAs, which can disrupt normal cellular function. For example, alternative polyadenylation can result in the expression of oncogenes or the loss of tumor suppressor genes in cancer. In neurological disorders, defects in polyadenylation can affect the expression of proteins critical for neuronal function and development.
