How Does Alternative Polyadenylation Affect Gene Expression?
Alternative polyadenylation (APA) refers to the use of different polyadenylation sites within the same gene, leading to the generation of mRNA isoforms with variable 3' untranslated regions (UTRs). APA can affect gene expression by influencing mRNA stability, localization, and translation efficiency. The choice of polyadenylation site can be regulated by various factors, including cell type, developmental stage, and external stimuli. Understanding APA is crucial for comprehending the complexity of gene regulation and its impact on cellular function.
