How are Polyadenylation Sites Studied in Histology?
In histology, the study of polyadenylation sites is often integrated with techniques such as in situ hybridization and immunohistochemistry to localize and quantify mRNA expression within tissue samples. Researchers may use specific probes that bind to the poly(A) tail or the sequences surrounding polyadenylation sites to study their distribution and regulation in different cell types and tissues. Additionally, high-throughput sequencing techniques like RNA-Seq can provide detailed information about the polyadenylation landscape in various biological contexts.
