forkhead box o1

What is the Relationship Between FOXO1 and Metabolism?

FOXO1 has a significant impact on metabolism. In the liver, it regulates gluconeogenesis by activating the transcription of genes such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase. In adipose tissue, FOXO1 influences adipogenesis and lipid metabolism by modulating the expression of genes like adiponectin and leptin.

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