What is the Role of FOXO1 in Cell Cycle Regulation?
FOXO1 plays a vital role in cell cycle regulation by modulating the transcription of genes that control cell cycle progression and arrest. For example, FOXO1 can activate the expression of cyclin-dependent kinase inhibitors such as p27Kip1 and p21Cip1, which are crucial for cell cycle arrest at the G1 phase.