mononuclear phagocyte

What is the Origin of Mononuclear Phagocytes?

Mononuclear phagocytes originate from hematopoietic stem cells in the bone marrow. These stem cells differentiate into myeloid progenitors, which then give rise to monocytes. Upon entering tissues, monocytes differentiate into macrophages or dendritic cells, depending on the signals in the local environment.

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