What is the Histological Appearance of Megakaryocytes Under the Influence of TPO?

Under the influence of TPO, megakaryocytes exhibit several histological changes. These cells become significantly larger and show increased ploidy due to endomitosis. Histologically, megakaryocytes have a large, lobulated nucleus and abundant cytoplasm. The cytoplasm appears granular and is filled with platelet-producing demarcation membranes. In bone marrow biopsies, the presence of numerous large megakaryocytes with multiple nuclear lobes can be indicative of active TPO influence.