Are There Any Histological Changes in Diseases Affecting TPO Levels?
Yes, several diseases affecting TPO levels can lead to characteristic histological changes in the bone marrow. In conditions like myelodysplastic syndromes (MDS) and aplastic anemia, where there is ineffective or reduced platelet production, the bone marrow may show hypocellularity with a reduced number of megakaryocytes. Conversely, in conditions like essential thrombocythemia, there is an overproduction of platelets, and the bone marrow shows hypercellularity with an increased number of megakaryocytes, often with abnormal morphology.
