Thrombopoietin (TPO) is a crucial glycoprotein hormone responsible for the regulation of platelet production. It is primarily produced in the liver and kidneys and plays a significant role in the hematopoietic system. TPO acts by binding to its receptor, c-Mpl, found on the surface of megakaryocytes and their precursors. This interaction stimulates the proliferation and differentiation of megakaryocytes, leading to increased platelet production.
