The primary function of PINK1 is to regulate mitochondrial quality control. It does so by initiating the removal of dysfunctional mitochondria through mitophagy. When mitochondria are damaged, PINK1 accumulation on the outer mitochondrial membrane recruits another protein called Parkin. Together, PINK1 and Parkin work to label the damaged mitochondria for degradation and removal. This process is crucial for maintaining cellular health, especially in neurons, which are highly dependent on functional mitochondria.
