Transcription: Collagen genes are transcribed into mRNA in the cell nucleus. Translation: The mRNA is translated into pre-procollagen in the rough endoplasmic reticulum. Post-translational Modifications: Hydroxylation and glycosylation of specific amino acids occur, converting pre-procollagen into procollagen. Triple Helix Formation: Three procollagen chains assemble into a triple helix structure. Secretion: Procollagen is secreted into the extracellular space, where it is cleaved to form mature collagen fibrils.
