What are the histological changes observed in PINK1-related diseases?

In diseases associated with PINK1 mutations, such as Parkinson's disease, histological examination often reveals the presence of Lewy bodies, which are abnormal aggregates of protein that develop inside nerve cells. Additionally, there may be evidence of neuronal loss, gliosis (a reactive change of glial cells), and mitochondrial dysfunction. These changes can be observed in brain regions such as the substantia nigra, which is critically affected in Parkinson's disease.