Ankyrin 2 is involved in the stabilization and localization of various membrane proteins, which are essential for maintaining cell structure and function. It facilitates the anchoring of ion channels, cell adhesion molecules, and transporters to the cytoskeleton. This ensures proper cellular signaling and homeostasis. In cardiomyocytes, ankyrin 2 is particularly important for the maintenance of normal heart rhythm by anchoring ion channels such as the Na+/K+-ATPase and the Na+/Ca2+ exchanger.
