Mutations in the ANK2 gene have been linked to several cardiovascular disorders, most notably arrhythmogenic conditions such as Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), and Sinus Node Dysfunction. These mutations can lead to the mislocalization of ion channels, resulting in impaired cardiac excitability and rhythm. Understanding the role of ankyrin 2 in these conditions can aid in the development of targeted therapies and diagnostic tools.
