Mutations or dysregulation of SNAP-25 have been linked to various neurological disorders, including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder (ADHD). Additionally, toxins such as botulinum toxin target SNAP-25, cleaving the protein and preventing neurotransmitter release, which leads to muscular paralysis. Understanding SNAP-25's role in these conditions can provide insights into potential therapeutic approaches.
