How Does SNAP-25 Function in Neurotransmitter Release?
SNAP-25, along with syntaxin and synaptobrevin (also known as VAMP), forms the core of the SNARE complex. This complex is responsible for bringing the synaptic vesicle and the plasma membrane close together, facilitating their fusion. Upon the arrival of an action potential, calcium ions enter the presynaptic terminal and trigger the SNARE complex to undergo a conformational change. This change drives the fusion of the vesicle with the membrane, resulting in the release of neurotransmitters into the synaptic cleft.
