Hsp70 is implicated in various diseases and conditions:
Cancer: Overexpression of Hsp70 is often observed in cancer cells, where it contributes to tumor survival and resistance to therapy. Neurodegenerative Diseases: Hsp70 helps prevent the aggregation of misfolded proteins, which is a hallmark of diseases such as Alzheimer's and Parkinson's. Cardiovascular Diseases: Hsp70 provides protection against ischemia-reperfusion injury in the heart.