What is the Clinical Relevance of RNA Polymerase III?
Pol III dysfunction is associated with various diseases and pathological conditions:
Mutations in Pol III subunits or associated factors can lead to neurodevelopmental disorders, such as Pol III-related leukodystrophy. Pol III activity is often upregulated in cancer cells, making it a potential target for anti-cancer therapies. Autoimmune diseases like systemic sclerosis have been linked to autoantibodies targeting Pol III components.
Understanding Pol III's role in these conditions could pave the way for novel diagnostic and therapeutic approaches.
