The activity of Pol III is tightly regulated by various cellular mechanisms to ensure that RNA synthesis occurs appropriately. Key regulatory factors include:
Transcription factors such as TFIIIB and TFIIIC, which are necessary for Pol III to initiate transcription. Signaling pathways like the mTOR pathway, which can modulate Pol III activity in response to nutrient availability and other cellular conditions. Epigenetic modifications, such as DNA methylation and histone acetylation, that influence Pol III accessibility to its target genes.
