Inositol-requiring enzyme 1 (IRE1) is a crucial protein that functions as both a kinase and an endoribonuclease. It plays a significant role in the unfolded protein response (UPR), which is a cellular stress response related to the endoplasmic reticulum (ER). The UPR is activated in response to the accumulation of unfolded or misfolded proteins in the ER lumen.
