1. Safety of Laboratory Personnel: Repeated exposure to high-toxicity chemicals can lead to serious health issues, including respiratory problems, skin irritation, and even long-term conditions such as cancer. Using low-toxicity reagents minimizes these risks. 2. Preservation of Tissue Samples: High-toxicity chemicals can sometimes alter the cellular structure or composition of tissue samples, leading to inaccurate results. Low-toxicity reagents help preserve the natural state of the tissues. 3. Environmental Concerns: Many high-toxicity chemicals are also environmentally hazardous. Low-toxicity alternatives reduce the environmental impact of histological practices.