What are the Pathological Implications of IRE1 Dysregulation?
Dysregulation of IRE1 has been implicated in various diseases, such as neurodegenerative diseases, cancer, and metabolic disorders. For instance, chronic ER stress and IRE1 activation are associated with the pathogenesis of Alzheimer's disease due to the accumulation of misfolded proteins. In cancer, IRE1 can influence tumor progression by modulating the UPR and affecting cell survival and proliferation.
