What is centrosome duplication and how is it regulated?
Centrosome duplication is a tightly regulated process that occurs once per cell cycle to ensure that each daughter cell receives one centrosome. This process is regulated by a range of proteins, including cyclin-dependent kinases (CDKs) and the polo-like kinase 4 (Plk4). Dysregulation of centrosome duplication can lead to centrosome amplification and genomic instability.
