CD31, also known as Cluster of Differentiation 31 or PECAM-1 (Platelet Endothelial Cell Adhesion Molecule), is a protein encoded by the PECAM1 gene in humans. It is a member of the immunoglobulin superfamily and is primarily expressed on the surface of endothelial cells, which line blood vessels. CD31 plays a crucial role in various cellular processes, including angiogenesis, immune response, and leukocyte transmigration.