In histological studies, cell cycle dysregulation can be detected using various techniques: 1. Immunohistochemistry (IHC): IHC can detect the expression of cell cycle proteins like cyclins, CDKs, and tumor suppressors in tissue sections. 2. Flow Cytometry: This technique measures DNA content and can identify cells in different phases of the cell cycle. 3. Fluorescence In Situ Hybridization (FISH): FISH can identify chromosomal abnormalities and gene amplifications associated with dysregulation.