cell cycle dysregulation

How is Dysregulation Detected in Histology?

In histological studies, cell cycle dysregulation can be detected using various techniques:
1. Immunohistochemistry (IHC): IHC can detect the expression of cell cycle proteins like cyclins, CDKs, and tumor suppressors in tissue sections.
2. Flow Cytometry: This technique measures DNA content and can identify cells in different phases of the cell cycle.
3. Fluorescence In Situ Hybridization (FISH): FISH can identify chromosomal abnormalities and gene amplifications associated with dysregulation.

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