What Histological Changes are Associated with Syphilis?
Syphilis can induce a variety of histological changes depending on the stage of the disease. In primary syphilis, one might observe an inflammatory infiltrate rich in plasma cells, macrophages, and lymphocytes. Secondary syphilis can show more widespread tissue involvement, including endarteritis and periarteritis. In tertiary syphilis, granulomatous inflammation forming gummas can be identified in various tissues, including the skin, liver, and bones.
