Two primary enzyme families are involved in histone acetylation and deacetylation:
1. Histone Acetyltransferases (HATs): These enzymes add acetyl groups to histones, facilitating an open chromatin state and promoting transcriptional activation. 2. Histone Deacetylases (HDACs): These enzymes remove acetyl groups from histones, leading to chromatin compaction and transcriptional repression.