Microglial proliferation can be stimulated by several factors: 1. Pathogens: Infection by bacteria, viruses, or other microorganisms can trigger a proliferation response. 2. Injury: Physical damage to CNS tissue can induce microglial proliferation as part of the repair process. 3. Neurodegenerative Diseases: Conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis can lead to increased microglial activity and proliferation.
