In genetic skin disorders, specific changes can be observed in the various skin layers:
Epidermis: Abnormalities in keratinocytes, leading to blistering in EB. Dermis: Defective collagen or elastin fibers in EDS, resulting in hyper-elastic skin. Basement Membrane Zone: Mutations in proteins like laminin or type VII collagen can lead to separation in this zone, commonly seen in EB.
