In histology, HSCs can be identified using specific markers and staining techniques. Common markers include CD34, a surface protein, and CD133. Immunohistochemistry (IHC) and flow cytometry are commonly used techniques to identify and isolate HSCs based on these markers. Additionally, HSCs can be visualized in bone marrow biopsies using hematoxylin and eosin (H&E) staining, although they are not easily distinguishable without specific markers.