What is Silver Enhanced In Situ Hybridization (SISH)?
Silver Enhanced In Situ Hybridization (SISH) is a molecular technique used in histology to detect specific nucleic acid sequences within tissue sections. This method combines traditional in situ hybridization with a silver enhancement step, which improves the sensitivity and visualization of the hybridization signals. SISH is particularly useful for detecting low-abundance targets and provides a permanent, highly contrastable signal.
