What Are the Primary Histological Features of Alzheimer's Disease?
Two hallmark histological features of Alzheimer's disease are amyloid plaques and neurofibrillary tangles. Amyloid plaques are extracellular deposits primarily composed of beta-amyloid (Aβ) peptides, while neurofibrillary tangles are intracellular aggregates of hyperphosphorylated tau protein. These pathological structures disrupt neuronal function and are pivotal in the progression of AD.
