What are the Pathological Features of TDP-43 Proteinopathies?
The pathological features of TDP-43 proteinopathies include:
Cytoplasmic Aggregation: TDP-43 relocates from the nucleus to the cytoplasm and forms aggregates. Nuclear Clearance: Loss of nuclear TDP-43 is a significant pathological hallmark. Phosphorylation and Ubiquitination: TDP-43 in inclusions is often phosphorylated and ubiquitinated. Fragmentation: TDP-43 can be cleaved into smaller fragments that are prone to aggregation.
