What Histological Techniques are Used to Study TDP-43?
Several histological techniques are employed to study TDP-43, including:
Immunohistochemistry (IHC): This technique uses antibodies specific to TDP-43 to visualize its distribution and aggregation in tissue sections. Western Blotting: Used to detect and quantify TDP-43 and its modified forms in tissue extracts. Immunofluorescence: Allows for the visualization of TDP-43 in cells using fluorescently labeled antibodies. Electron Microscopy: Provides detailed ultrastructural information on TDP-43 inclusions.
