tdp 43

What Histological Techniques are Used to Study TDP-43?

Several histological techniques are employed to study TDP-43, including:
Immunohistochemistry (IHC): This technique uses antibodies specific to TDP-43 to visualize its distribution and aggregation in tissue sections.
Western Blotting: Used to detect and quantify TDP-43 and its modified forms in tissue extracts.
Immunofluorescence: Allows for the visualization of TDP-43 in cells using fluorescently labeled antibodies.
Electron Microscopy: Provides detailed ultrastructural information on TDP-43 inclusions.

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