How is TDP-43 linked to Neurodegenerative Diseases?
TDP-43 is most notably associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). In these conditions, TDP-43 aggregates in the cytoplasm of affected neurons, forming inclusions. These inclusions are a hallmark of pathology and are often detected using histological techniques such as immunohistochemistry.
