What are the Pathological Conditions Associated with Cytokine Dysregulation?
Dysregulation of cytokine production or signaling can lead to various pathological conditions. Overproduction of pro-inflammatory cytokines is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Conversely, insufficient cytokine production can result in impaired immune responses, as seen in certain immunodeficiency disorders. Additionally, cytokine storms, characterized by excessive release of cytokines, can lead to severe tissue damage and are observed in conditions like sepsis and severe viral infections.
