What are the Negative Consequences of Glial Scar Formation?
Although the glial scar plays an essential protective role, it can also have detrimental effects:
- Inhibition of Axonal Regeneration: The dense ECM components, particularly CSPGs, create a non-permissive environment for axonal growth, hindering the regeneration of damaged neurons. - Chronic Inflammation: Persistent activation of glial cells can lead to chronic inflammation, which may exacerbate tissue damage and contribute to ongoing neurodegeneration.
