What are the Therapeutic Approaches to Modulate Glial Scar Formation?
Research is ongoing to develop therapeutic strategies that can modulate glial scar formation to promote CNS repair. Some of the approaches include:
- Enzymatic Degradation of ECM Components: Enzymes like chondroitinase ABC can degrade CSPGs, reducing the inhibitory effects of the glial scar on axonal regeneration. - Anti-inflammatory Treatments: Drugs that target inflammatory pathways can reduce chronic inflammation and support a more regenerative environment. - Cell-based Therapies: Transplantation of stem cells or progenitor cells can provide new cells that aid in tissue repair and potentially replace lost or damaged neurons.
