What are the Mechanisms Behind Stress Induced Senescence?
Stress induced senescence involves complex signaling pathways. The p53/p21 and p16^INK4a/Rb pathways play crucial roles in mediating the senescence response. Upon detection of stress, p53 is activated and upregulates the expression of p21, which inhibits cyclin-dependent kinases (CDKs) leading to cell cycle arrest. Similarly, p16^INK4a inhibits CDK4/6, maintaining the retinoblastoma protein (Rb) in its hypophosphorylated state, thereby preventing cell cycle progression.
