How is Stress Induced Senescence Detected in Histology?
In histological studies, stress induced senescence can be identified by specific markers, such as the presence of senescence-associated β-galactosidase (SA-β-gal) activity. Additionally, cells undergoing senescence often exhibit changes in morphology, such as an enlarged and flattened shape. Immunohistochemistry can be employed to detect other markers like p16^INK4a, p21^CIP1, and γ-H2AX, which are indicative of DNA damage and cell cycle arrest.
