How Does Stress Induced Senescence Relate to Cancer?

While stress induced senescence acts as a barrier to cancer development by halting the proliferation of cells with potential oncogenic mutations, it can also have paradoxical effects. The SASP factors secreted by senescent cells can create a pro-tumorigenic environment that supports cancer cell growth and metastasis. Thus, understanding the dual role of senescence in cancer is crucial for developing targeted therapeutic strategies.